Abstract
BackgroundApolipoprotein A1 (ApoA1) is the major apoprotein constituent of high density lipoprotein (HDL) which exerts innate protective effects in systemic inflammation. However, its role in the acute lung injury (ALI) has not been well studied. In the present study we investigated the association between polymorphisms of ApoA1 gene and ALI in a Chinese population.MethodsThree polymorphisms of the ApoA1 gene (rs11216153, rs2070665, and rs632153) were genotyped by TaqMan method in 290 patients with sepsis-associated ALI, 285 patients sepsis alone and 330 age- and sex-matched healthy controls.ResultsWe found rs11216153 polymorphism of ApoA1 was associated with ALI, the GG genotype and G allele was common in the ALI patients (76.9%, 88.1%, respectively) than both in the control subjects (55.8%, 75.8%, respectively) and in the sepsis alone patients (58.2%, 78.4%, respectively). Haplotype consisting of these three SNPs strengthened the association with ALI susceptibility. The frequency of haplotype GTG in the ALI samples was significantly higher than that in the healthy control group (OR = 2.261, 95% CI: 1.735 ~ 2.946, P <0.001) and the sepsis alone group (OR = 1.789, 95% CI: 1.373 ~ 2.331.P < 0.001). Carriers of the haplotype TTG had a lower risk for ALI compared with healthy control group (OR = 0.422, 95% CI: 0.310 ~ 0.574, P < 0.001) and sepsis alone group (OR = 0.491, 95% CI: 0.356 ~ 0.676, P <0.001).ConclusionsThese results indicated that genetic variants in the ApoA1 gene might be associated with susceptibility to sepsis-associated ALI in Han Chinese population.
Highlights
Acute lung injury (ALI) and its more severe form, the acute respiratory distress syndrome (ARDS), are syndromes of acute respiratory failure that are characterized by acute pulmonary edema and lung inflammation
Associations of the Apolipoprotein A1 (ApoA1) gene SNPs with acute lung injury (ALI) risk Table 2 shows the distribution of the genotypes and alleles of these 3 SNPs
We found rs11216153 polymorphism of ApoA1 was associated with ALI, the GG genotype and G allele was common in the ALI patients (76.9%, 88.1%, respectively) than both in the control subjects (55.8%, 75.8%, respectively, P < 0.001) and in the sepsis alone patients (58.2%, 78.4%, respectively, P < 0.001)
Summary
Acute lung injury (ALI) and its more severe form, the acute respiratory distress syndrome (ARDS), are syndromes of acute respiratory failure that are characterized by acute pulmonary edema and lung inflammation. Previous study [13] suggested that one variant residing in the ApoA1 gene, which involves a guanine to adenine transition 75 base pairs (bp) upstream from the start of transcription (G–75A) and destroys a site for the MspI restriction enzyme, was associated with ALI after cardiopulmonary bypass surgery. The authors only selected one single nucleotide polymorphism (−75 G > A) to perform a case–control study This is a hospital based case–control study, the selection bias cannot be avoidable and the subjects may not be representative of the general population. In the present study we investigated the association between polymorphisms of ApoA1 gene and ALI in a Chinese population
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