Сhanges in depolarization processes of ventricular extrasystole in patients with arrhythmogenic cardiomyopathy/right ventricular dysplasia: fragmentation and maximum duration of QRS complex

Abstract

Background:There are new characteristics of ventricular extrasystole (VE): the QRS interval maximum duration (VEQSI max.) and its fragmentation (fQRS), which are insufficiently studied in patients with ARVD/C.Objective:To analyze VEQSI max. and fQRS of VE depending on frequency of SCD, syncope, ICD and ICD-shocks in patients with ARVD/C.Materials and methods: Included 83 patients:(41 m, 30.3±4.1 years): 55 (27 m) with the established (ED), 13 (5 m) — borderline, 15 (9 m) — possible diagnosis of ARVD/C [Marcus F.I., 2010].Results:Syncope were in 34 patients (41,0%, 19 m): mostly (70,5%, 15 m) in the ED. SCD — in 5 patients (2,4%, 4 m): 80,0% with the ED. ICD was implanted to 31 patients (37,3%, 21 m) in 87,1% ED. ICDshocks- in 15 patients (48,4%,11 m) with the ED. The average VEQSI max was 168,1±23,1ms, significantly higher inED (р<0,05), and in men (р<0,05). FQRS was discovered in ED (10,8%) and possible diagnosis (13,3%), in the leads II, III, V5-V6.Conclusions:Syncope, SCD, ICD implanting and shocks were occurred more often in patients with the established diagnosis of ARVD/C. VEQSI max. was higher in that group.