Abstract
Background HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a chronic disabling disease caused by the retrovirus HTLV-1. It is a horrible, chronic, progressing disease causing weakness of lower limbs, bladder, bowel and erectile dysfunction, as well as pain in the lower back and legs. HAM/TSP is associated with significantly higher mortality and morbidity than the general population. Currently there is no cure or antiviral treatment for HTLV-1 and no internationally agreed treatment for patients with HAM/TSP. We had two aims: to identify the level of evidence of current medicinal treatment strategies available to patients and clinicians and to identify drugs that should be pursued for future clinical trials.
Highlights
HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a chronic disabling disease caused by the retrovirus HTLV-1
HAM/TSP is associated with significantly higher mortality and morbidity than the general population
We had two aims: to identify the level of evidence of current medicinal treatment strategies available to patients and clinicians and to identify drugs that should be pursued for future clinical trials
Summary
HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a chronic disabling disease caused by the retrovirus HTLV-1. It is a horrible, chronic, progressing disease causing weakness of lower limbs, bladder, bowel and erectile dysfunction, as well as pain in the lower back and legs. HAM/TSP is associated with significantly higher mortality and morbidity than the general population. There is no cure or antiviral treatment for HTLV-1 and no internationally agreed treatment for patients with HAM/TSP. We had two aims: to identify the level of evidence of current medicinal treatment strategies available to patients and clinicians and to identify drugs that should be pursued for future clinical trials
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