Abstract
Adult female Sprague-Dawley rats were implanted with chronic cortical EEG electrodes and Intravenous cannulae. U-50,488H injection (5.0 mg/kg) produced Initial EEG desynchrony and EEG spectral power that was mainly distributed over the zero to 10 Hz range, including a relatively small spectral peak in the 4–6 Hz band. In contrast, following haioperidol pretreatment (0.1 mg/kg), U-50,488H injection produced high-voltage EEG bursts and a predominant EEG spectral peak in the 4–6 Ha band. These effects of U-50,488H after haloperidol pretreatment were identical to those previously demonstrated with the benzomorphan kappa agonist ethylketocyclazoclne. Thus, haloperidol.pretreatment unmasked the kappa opiold effects of U-50, 488H.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
