Abstract
The Ca 2+ channel antagonist action of the antipsychotic haloperidol was investigated using two functional assays of Ca 2+ channel activity. Haloperidol dose dependently attenuated the rise in intracellular free Ca 2+ ([Ca 2+] i) evoked by 50 mM extracellular K + in Fura-2 loaded cultured rat hippocampal neurones with an IC 50 (± S.E.M.) of 7.8 ± 0.5 μM and similarly reduced whole-cell Ba 2+ currents ( I Ba) in voltage-clamped mouse hippocampal neurones with an IC 50 value of 15.6 ± 1.1 μM. Block of whole-cell I Ba by haloperidol was rapid, fully reversible, and was greater at more depolarized membrane potentials. Our data indicate that haloperidol non-selectively blocks neuronal voltage-gated Ca 2+ channels at micromolar concentrations.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: European Journal of Pharmacology: Molecular Pharmacology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.