Abstract
Halogenation reactions involving highly reactive halogenating agents can be performed safely and with improved efficiency and selectivity under continuous flow conditions.
Highlights
7 out of the top-10 best-selling drugs in the US in 2014 were halogenated compounds.[4]
Continuous flow chemistry offers unique opportunities to expand the array of synthetic methods available to the organic chemist
Very fast and exothermic reactions and transformation that require highly reactive, toxic, or corrosive reagents are the prototype examples in which moving from classical batch reactor to flow is the best solution.[71]
Summary
7 out of the top-10 best-selling drugs in the US in 2014 were halogenated compounds (some examples are shown in Fig. 1).[4] Almost 5000 naturally occurring organic halogenated compounds have been identified so far.[5] The beneficial. David Cantillo obtained his PhD from the University of Extremadura, Spain in 2011. His PhD focused on the experimental and theoretical study of 1,3-dipolar cycloadditions of mesoionic compounds. Kappe Group at the University of Graz as a postdoctoral associate. Since this time his research interests and experience involve computational chemistry, flow. David Cantillo photochemistry, photoredox catalysis, flow chemistry in extreme process windows and multistep API synthesis
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