Abstract
Four cases of hairy cell leukemia wire studied by immunofluorescence. All hairy cells bore surface immunoglobulin. In two cases, only IgD was detected on the cell surface, whereas both IgM and IgD were present in the other two cases. After adsorbed IgG was removed by overnight culture, only one class of light chains was detected. In addition, most of the hairy cells were capable of ingesting latex particles. These findings suggest that hairy cell leukemia is caused by a monoclonal proliferation of a type of Ig‐bearing B cell with phagocytic potential.
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