Abstract

Aim: The haematinic activity of the aqueous extract of Lophira lanceolata leaves was investigated using rat model of phenylhydrazine-induced anaemia.
 Methods and Results: Red Blood Cell (RBC) count, Haemoglobin (Hb) concentration and Packed Cell Volume (PCV) were analysed as indices of anaemia. Following phenylhydrazine administration to rats at a dose of 10 mg/kg for 8 days, a significant decrease (P<0.05) in the haematological parameters was observed indicating anaemia. However, treatment with graded doses (200, 400 and 800 mg/kg) of the aqueous extract of Lophira lanceolata leaves produced a significant (P<0.05) increase in the RBC count, Hb concentration and PCV time- and dose- dependently.
 Conclusion: It was concluded that Lophira lanceolata leaves possess haematinic activity, making it useful in the management of anaemia.

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