Gutartige Veränderungen der Brustdrüse, welche ein Karzinom vortäuschen

Abstract

Various mammary lesions may offer considerable clinical as well as histological difficulties concerning the biological behaviour. Among them are sclerosing adenosis, ductular papillomas, proliferating types of fibrocystic disease and lobular neoplasia. Between 1975 and 1978 3,243 mammary specimens were examined: 36% were carcinomas and very rare other primary malignancies, 12% sclerosing adenosis, 11% cysts, 12% benign tumors (fibroadenoma etc.), 28% fibrous cystic disease of which 6% were of the proliferating type. Nearly 0.6% were lobular neoplasia (so-called non-invasive lobular carcinoma, lobular carcinoma in situ). Lobular neoplasia shows a higher risk of developing into carcinoma than do the proliferative fibrocystic lesions. However, lobular neoplasia without concomitant carcinoma should not be interpreted as malignant, allowing a more conservative therapy. The histopathologic diagnosis is subject to limitations due to the technique of tissue sampling and examination. Borderline cases deserve extensive and careful scrutiny and should not be judged by intraoperative frozen sections alone.