Abstract
Summary Pony and horse foals were given daily intramuscular injections of dexamethasone, beginning at 6 months of age. Ponies were injected with 0 or 0.5 mg/100 kg bodyweight for 3, 8, or 11 months, or with 5.0 mg/100 kg for 11 months. Horses were treated with 0 or 5.0 mg/100 kg for 20 weeks. Rates of gain were inhibited (P . 10). Urinary nitrogen loss increased within 3 months (P Samples of left femur growth cartilage taken from ponies killed after 3 and 8 months were analyzed. Deoxyribonucleic acid content ( u g/ mg dry cartilage) was doubled by treatment (P Growth inhibition appeared to result from the production of abnormal growth cartilage, deficient in collagen and glycosaminoglycans. A metabolic shift from energy production to intra-chondrocyte energy storage, as reflected by decreased lactate dehydrogenase activities, appeared responsible for the decreased production of cartilage components.
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