Abstract
In The Lancet Infectious Diseases, Judith Absalon and colleagues1 report on a phase 1/2 clinical trial evaluating the safety, tolerability, and immunogenicity of a vaccine composed of capsular polysaccharide conjugated to cross-reactive material 197 (CRM197) and directed against six capsular polysaccharide serotypes of group B streptococcus (GBS). These serotypes (Ia, Ib, II, III, IV, and V) account for the vast majority of isolates causing invasive GBS disease worldwide—in neonates as well as in adults.
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