Abstract
BackgroundGremlin-1, a bone morphogenetic protein (BMP) antagonist, is up-regulated in osteoarthritis (OA). Therefore, we aim to evaluate the correlation between gremlin-1 concentrations and the onset and severity of OA.Material/MethodsWe performed this cross-sectional study in a population of 212 patients with knee OA and 125 healthy controls.ResultsPatients with knee OA had higher serum gremlin-1 concentrations than healthy controls. Serum and synovial fluid (SF) gremlin-1 concentrations increased according to advanced Kellgren-Lawrence grading stages.ConclusionsSerum and SF gremlin-1 concentrations are correlated with the onset and severity of knee OA.
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