Abstract
Green synthesis of silver nanoparticles (AgNPs) using different plant parts has shown a great potential in medicinal and industrial applications. In this study, AgNPs were in vitro green synthesized using A. graecorum, and its antifungal and antitumoractivities were investigated. Scanning electron microscopy (SEM) image result indicated spherical shape of AgNPs with a size range of 22‐36 nm indicated by using Image J program. The functional groups indicated by Fourier‐transform infrared spectroscopy (FTIR) represented the groups involved in the reduction of silver ion into nanoparticles. Alhagi graecorum AgNPs inhibited MCF‐7 breast cancer cell line growth in increased concentration depend manner, significant differences shown at 50, 100, and 150 μg/ml concentrations compared to the control. Strong antifungal activity against Candida species (C. albicans., C. glabrata, C. parapsilosis, C. tropicales, and C. krusei) was observed and the inhibition zone range from 14‐22 mm at a concentration of 0.01 mmol/ml and from 17‐27 mm at a concentration of 0.02 mmol/ml. Based on our findings, it is concluded that synthesized silver nanoparticles from A. graecorum can be used as a potential antitumor and antifungal agent for various therapeutical applications.
Highlights
The passion for nanotechnology applications has increased recently, as nanoscale materials facilitated a major breakthrough in research and human life
The biological activity of the silver nanoparticle solution was tested against species of pathogenic yeast (C. albicans, C. tropicales, C. parapsilosis, C. krusei, and C. glabrata) by using well diffusion method, and SDA plate dishes were cultured with Candida sp. growth
A gradual change in extract color from dark yellow to dark brown occurred after adding (0.01 and 0.02 mmol/ml) AgNO3 as a first conformation sight of silver nanoparticle synthesis (Figure 1). These results suggested that the exciting of reducing compounds in extract solution plays a significant role in conversion of silver ion Ag+ into Ag0 nanoparticles
Summary
The passion for nanotechnology applications has increased recently, as nanoscale materials facilitated a major breakthrough in research and human life. The presence of different phytomolecules in plants such as polyphenol, flavonoids, varies proteins, and sugars act as reducing and coating agents in the of NPs. a number of issues such as the synthesized methods used for Journal of Nanomaterials temperature and time, pH and pressure, and size and morphology significantly impact the synthesized nanoparticles using green technology and consciously their influence on cell behavior. Metallic nanoparticles have several properties including stability, and activity and its distinguishing surface plasmon resonance make it as an effective drug carrier and diagnosis therapeutic agent. Gold NPs were synthesis from A. maurorum flower, and the average rang of size particles was of 12-24 nm and with high stability and antimicrobial activity which suggested an efficient and consistent synthesis method [17]. The current study was designed to achieve the synthesis of AgNPs from aqueous extract of A. graecorum and determined the characteristic properties of newly synthesized NPs and assessment of its antifungal activity
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
