Abstract
AbstractA series of biologically important 3‐substituted‐2‐thixo‐4‐quinazolinones have been synthesized starting from methyl 2‐isothicyanatobenzoate and amines without the use of additives under mild reaction conditions in water. This transformation tolerates a wide range of amines, which include anilines, alkyl amines, and hydrazines, to afford 60 diverse 3‐substituted‐2‐thixo‐4‐quinazolinones including 34 new compounds at 60 °C for 30 min in good yields. This method avoids the use of organic solvent and the generation of toxic waste to demonstrate a cost efficient, green and sustainable method for the synthesis of 2‐thixo‐4‐quinazolinone derivatives as valuable heterocycles for biological and materials studies.
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