Abstract
The present study was conducted to develop a simple and novel synthesis process, one-step Salvia officinalis extract-assisted biosynthesis route to synthesize ZnO/Magnetite-based nanocomposites (ZnO/Mgt-NCs). Characterization of the physicochemical properties of the ZnO/Mgt-NCs was performed using XRD, FESEM, EDX, TEM, FT-IR, and DLS techniques. Furthermore, their biomedical properties for antibacterial properties and wound healing activity were assessed. According to the TEM and FESEM image, the synthesized spherical Fe3O4 nanoparticles on the surface of quartz were formed ranging from about 13–14 nm. In addition, based on the EDX spectra, the elemental analysis showed the presence of Zinc, Oxygen, and Iron elements in the as-synthesized ZnO/Mgt-NCs. Biomedical studies confirmed that ZnO/Mgt-NCs had antibacterial properties and demonstrated antibacterial activity against Streptococcus pyogenes and Pseudomonas aeruginosa. It also revealed infected wound healing activity by decreasing the total bacterial tissue on top of improving granulation tissue, collagen density and epithelization. Therefore, the new Magnetite-based ZnO/Mgt-NCs has greater potential to cure wounds efficiently.
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