Abstract
One of the most promising methods against drug-resistant bacteria can be surface-modified materials with biocidal nanoparticles and nanocomposites. Herein, we present a nanocomposite with silver nanoparticles (Ag-NPs) on the surface of graphene oxide (GO) as a novel multifunctional antibacterial and antifungal material. Ultrasonic technologies have been used as an effective method of coating polyurethane foils. Toxicity on gram-negative bacteria (Escherichia coli), gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and pathogenic yeast (Candida albicans) was evaluated by analysis of cell morphology, assessment of cell viability using the PrestoBlue assay, analysis of cell membrane integrity using the lactate dehydrogenase assay, and reactive oxygen species production. Compared to Ag-NPs and GO, which have been widely used as antibacterial agents, our nanocomposite shows much higher antimicrobial efficiency toward bacteria and yeast cells.
Highlights
The development of antibiotics has played a significant role in controlling the number of bacterial infections
The discovery of antibiotics, natural products produced by microorganisms that are able to prevent the growth of bacteria and cure infectious diseases, revolutionized medical therapy; the overuse and misuse of antibiotics have been key factors contributing to antibiotic resistance
Silver nanoparticles (Ag-NPs), graphene oxide (GO), and Ag-GO nanocomposites demonstrated the antibacterial activity that is stronger against gramnegative bacteria (E. coli) versus gram-positive bacteria (S. aureus and S. epidermidis) and yeast (C. albicans)
Summary
The development of antibiotics has played a significant role in controlling the number of bacterial infections. The improper use and the overuse of antibiotics have led to the development of multidrug resistance in many bacterial species. The major resistant pathogens are methicillinresistant Staphylococcus aureus, vancomycin-resistant Enterococcus, and extended-spectrum β-lactamaseproducing Klebsiella pneumoniae and Escherichia coli [2, 3]. Bacteria, with their very large populations and fast proliferation time, are able to rapidly develop mechanisms of antibiotic resistance when a subset of the bacteria population survives antibiotic treatment. Antibioticresistant bacteria are able to transfer copies of DNA that code for a mechanism of resistance to other distantly
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
