Abstract
AbstractThis article examines the possibility of using the microscope methods in conjunction with an image processor (Kontron IBAS 2000) to granulometrically characterise ibuprofen lysinate, a recently discovered soluble salt of ibuprofen (analgesic, anti-inflammatory and antipyretic). Likewise, the advantages this method has over conventional microscope methods and other existing procedures are analysed. The methodology applied is described and the findings reported. The crystal morphology of ibuprofen lysinate is acicular. All parameters determined follow a log-normal distribution pattern and not a Gauss distribution pattern. The Feret diameter distribution did not follow either of these patterns. As a result, the Feret diameters are the least representative parameters of this active agent's granulometry. On the other hand, the equivalent diameter is the most representative parameter. From a technological and pharmaceutical point of view, the drugs' appearance is that of a granulometrically homogenous p...
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