Abstract
BackgroundNeutrophil-to-lymphocyte ratio (NLR) has been shown to be a predictor of patients’ outcome for several types of malignancies.FindingsUsing multicolor flow cytometry we searched for predictive markers to monitor blood immune cells in patients with renal cell carcinoma undergoing surgery of the primary tumor. Due to a high standard deviation, pre-surgery NLR values did not significantly differ between tumor patients and the control group. In contrast, the granulocyte-to-dendritic cell (DC) ratio revealed significant higher values in tumor patients. Whereas NLR values did not differ between patients with early stage tumors and locally advanced tumors, the granulocyte/DC ratio was significantly different in these groups. Additionally, comparison of both ratios before and after tumor resection in the two groups “open surgery” and “laparoscopy” could demonstrate the suitability of granulocyte/DC ratio as a marker for immune monitoring.ConclusionsGranulocyte/DC ratio may serve as a new putative biomarker for the immune monitoring of tumor patients.
Highlights
Neutrophil-to-lymphocyte ratio (NLR) has been shown to be a predictor of patients’ outcome for several types of malignancies
Granulocyte/dendritic cell (DC) ratio may serve as a new putative biomarker for the immune monitoring of tumor patients
We focused on the neutrophil-to-lymphocyte ratio (NLR), which has been shown to be a marker of systemic inflammatory response and a predictor of patients’ outcome in this disease [5,6]
Summary
Neutrophil-to-lymphocyte ratio (NLR) has been shown to be a predictor of patients’ outcome for several types of malignancies. In our study blood immune cells were investigated in RCC patients undergoing open or laparoscopic tumor surgery. We focused on the neutrophil-to-lymphocyte ratio (NLR), which has been shown to be a marker of systemic inflammatory response and a predictor of patients’ outcome in this disease [5,6]. We compared patients’ data with an age-matched control group, correlated pre-surgery markers with tumor stages and performed time kinetics in patient groups undergoing open or laparoscopic tumor surgery. Our data suggest that the granulocyte/DC ratio is a more valuable marker for the immune monitoring of RCC patients than granulocytes and DC (as sum of MDC1, MDC2, and PDC)
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