Abstract
ObjectiveGrain of paradise (GP; Aframomum melegueta) is an herbaceous plant from the ginger family. Two components of GP, paradol and gingerol, are structurally similar to capsaicin, a pungent compound with anti‐obese actions. Our group investigated the effects of GP‐extracts on energy expenditure and the prevention of obesity.MethodsWe investigated the effects of GP‐extracts on norepinephrine (NE)‐induced lipolysis in 3T3‐L1 cells, on the progression of obesity in high fat diet (HFD)‐induced obese mice, and on body weight and energy expenditure in humans receiving repeated doses of the extracts for 4 weeks.ResultsGP‐extracts accelerated lipolysis in 3T3‐L1 cells. In the obese mice, the extracts prevented HFD‐induced elevations in body and adipose tissue weights. In humans, the energy expenditure observed after the intake of GP‐extracts differed significantly from that observed before the intake.ConclusionGP‐extracts intake enhances the energy expenditure and basal metabolism in humans, possibly via an acceleration of lipolysis followed by fat combustion. The effects of GP‐extracts on energy expenditure are thought to be caused by paradol and gingerol major components of the extract.
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