Abstract
Objective We aimed to assess the expression level of GRAF gene in patients with acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) and to clarify its prognosticsignificance on the clinical outcome. Background GTPase regulator associated with focal adhesion kinase (GRAF) is a newly identified protein specifically binding to focal adhesion kinase and negatively regulates the small GTP-binding protein RhoA, which is well known for its growth-promoting effect in RAS-mediated malignant transformation. GRAF is recognized as a tumor suppressor gene that binds to focal adhesion kinase. Methods In this study, we investigated the expression of the GRAF transcript by realtime quantitative PCR in 37 AML patients, 35 CML patients and 15 healthy and sex-matched controls, and to clarify its prognostic significance on the clinical outcome. Results We found that the GRAF expression is low in patients with AML and CML. A high GRAF expression is a favorable prognostic marker in patients with AML and CML. In AML, high GRAF transcript. Conclusion High GRAF expression is a favorable prognostic marker in AML patients and a protective factor against CML progression.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
