Abstract
47 men who had been surgically treated for unilateral (UC,n=32) and bilateral cryptorchidism (BC,n=15) at 5-14 yrs were studied on follow-up at 16-28 yrs. In UC the volume of the operated testis was 11.9±0.7 ml (mean ± SEN) and of the contralateral testis 15.8± 0.7 ml. In BC the mean testicular volume was 11.3±0.9 ml. Sperm count was below 40 millions/ml in 12 UC (n=23) and 9 BC (n=13) with 5 of them below 1 million/ml. In all patients plasma LH and FSH were measured before and 10-120 tnin. after LHRH (25 ug/m2 i.v.). Basal FSH values were elevated in 5 UC and 10 BC, FSH response to LHRH was excessive in 2 UC and 8 BC. Basal LH values were within normal limits in all patients, but a high LH response was observed in 6 UC and 3 BC. Plasma testosterone was normal in all but 3 cases (2 UC, 1BC) where subnormal levels were found. This study reveals a high incidence of functional impairment of the germinal epithelium in cryptorchidism with compromised fertility in most cases with BC. Leydig cell function is affected in only a few cases of both UC and BC.
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