Abstract
In this study the novel hydrogel loaded with gold nanoparticle (AuNP) enhanced the berberine (BS) release when compared with other formulations of hydrogel. Hydrogels are hydrophilic polymer networks having the capacity to absorb water, ranging from about twenty to thousand times their dry weight. BS is a natural product, a quaternary ammonium salt from the group of isoquinoline alkaloids found in medicinal plants as Berberis Vulgaris. BS has some activity against dysentery, hypertension, inflammation, and liver disease in China and Japan. In this work, BS was used as a model drug to study its association with different types of hydrogel composites of polyvinyl alcohol (BS-PVA 10%); gellan gum (BS-GG 2%), gellan gum-PVA crosslinked with cysteine (cys) (BSGG2%PVA2%cys) and gellan gum-PVA cosslinked with cysteine associated with gold nanoparticles (AuNP-BSGG2%PVA2%cys). Several parameters such as fraction of retained water (Wf), hydration percentage (%H), Swelling (DSw) and time course profile (t = 100%) (TC) were evaluated for all preparations. The results showed that the AuNP-BS-GG2%PVA2%cys was able to retain more water and swelling than the other preparations. The time course of release of the BS to the medium was greater for AuNP-BS-GG2%PVA2%cys making it a candidate to drug delivery studies in biological assays. Also Scanning Electron Microscopy (SEM) images of the surface of these hydrogel were performed. Furthermore, crosslink of the resulting hydrogels were investigated by Fourier Transform Infrared Spectroscopy (FTIR) and differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Thus, briefly, the aim of this work was to study three composition of hydrogel loaded with BS and its composition in relation to addition to AuNP and evaluate its profile for further drug delivery application using the Surface Plasmonic Resonance (SPR) as a tool improving the drug release in the new hydrogel.
Highlights
Berberine (BS) is a natural product, a quaternary ammonium salt from the group of isoquinoline alkaloids, belongsto structural class of protoberberine, which positively-charged ion turns it hydro soluble
The first attempt to production of biodegradable hydrogel composite with PVA was done in 7.5% w/w this hydrogel type dissolved when added to solution of HEPES
By the use of the crosslink method, we have prepared several hydrogel composite by varying amount of gellan gum (GG) and PVA loaded with BS and its association to gold nanoparticles, and characterized its water holding capacities, time course release profile; physical-chemical behavior (FTIR, differential scanning calorimetry (DSC); thermogravimetric analysis (TGA)) and surface analysis (SEM)
Summary
Berberine (BS) is a natural product, a quaternary ammonium salt from the group of isoquinoline alkaloids, belongsto structural class of protoberberine, which positively-charged ion turns it hydro soluble. Hydrogels are able to mimic nature tissue, being biocompatibility [15] [16] This feature leads to the amount of storage a large amount of water and special surface property. In this background, synthetics hydrogels are awaken interest at tissue engineering, cell encapsulate and drug delivery [17]. Another type of nanomaterial that have attracted increasing attention due to their unique properties in multidisciplinary research fields are gold nanoparticles (AuNPs) [2] [3]. The particles absorb and resonantly scatter visible and near-infrared light upon excitation of their surface plasmon oscillation (SPR)
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