Abstract
A simple and sensitive electrochemical sensor was developed for the detection of tracelevels of luteolin. The sensoris based on a novel type of chemically modified electrode: gold nanocage (AuNCs)-modified carbon ionic liquid electrode (CILE). To construct this electrochemical sensing platform for luteolin, CILE is initially prepared by using 1-hexylpyridinium hexafluorophosphate as the binder and then AuNCs are coated on the surface of CILE to fabricate AuNCs-modified CILE (AuNCs/CILE). Electrochemical studies have shown that AuNCs/CILE can exhibit enhanced electrocatalytic activity toward the redox reaction of luteolin, therefore, the redox peak current of luteolin can be greatly improved, resulting in the high sensitivity of the developed sensor. Under the optimal conditions, the oxidation peak currents of the sensor increase linearly with an increase in the luteolin concentration in a range from 1 to 1000 nM with a detection limit of 0.4 nM, which is lower than those of most reported electrochemical luteolin sensors. Moreover, the reproducibility, precision, selectivity, and stability of this sensor are excellent. Finally, the sensing system was applied to the analysis of luteolin-spiked drug samples and the recovery in all cases was 95.0–96.7%, indicating the potential application of this simple, facile, and sensitive sensing system in pharmaceutical analysis.
Highlights
Luteolin (30,40,5,7-tetrahydroxyflavone) is an important flavonoid that is naturally present in a variety of plants, e.g., peppermint, green pepper, thyme, and parsley [1,2,3]
The results indicate that the redox reaction of luteolin had taken place on AuNCs/carbon ionic liquid electrode (CILE), To investigate the electrochemical behavior of luteolin on AuNCs/CILE, we carried out CV to which was in line the electrochemical reaction mechanism of luteolin on electrodes
The results indicate that the redox reaction of luteolin had taken place on AuNCs/CILE, which was in line with the electrochemical reaction mechanism of luteolin on electrodes [4,5]
Summary
Luteolin (30 ,40 ,5,7-tetrahydroxyflavone) is an important flavonoid that is naturally present in a variety of plants, e.g., peppermint, green pepper, thyme, and parsley [1,2,3]. To improve the sensitivity of electrochemical detection of luteolin, recent research has focused on the design of innovative, chemically modified electrodes based on various nanomaterials, such as multi-walled carbon nanotubes, macroporous carbon nanomaterials, graphene-hydroxyapatite nanocomposites, and In2 O3 nanoparticles [5,16,17,18,19,20] These nanomaterials exhibit excellent electrocatalytic activity toward the redox reaction of luteolin and lead to the amplification of the electrochemical signal. Due to the unique features of noble metal composition with hollow, porous, and thin-walled structure, AuNCs possess several distinctive properties over commonly used gold nanoparticles, including good chemical/thermal stability, high catalytic activity, strong localized surface plasmon resonance, and excellent controlled release properties [22,23,24,25] Such outstanding properties make them very attractive for many applications including catalysis, diagnostics, therapy, and spectral signal enhancement, which enable the constructed devices/methods with unparalleled performance [22,23,24,25]. The study aims to emphasize that AuNCs with superior electrocatalytic activity can be utilized as an alternative to previously used nanocatalysts in electrochemical sensing of luteolin
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
