Abstract

Glycosaminoglycans isolated from nonpregnant and pregnant human cervical uteri were characterized by cellulose-acetate electrophoresis, ion-exchange chromatography, enzymatic digestion, and nitrous acid oxidation. The cervical glycosaminoglycans mainly consisted of dermatan sulfate with hyaluronic acid, chondroitin 4- and 6-sulfate, and heparan sulfate. No effect of pregnancy on the content of glycosaminoglycans in the defatted tissue was found, but the proportion of them in the tissue changed markedly. Thus, a marked increase in heparan sulfate and a decrease in dermatan sulfate was confirmed in the cervix in pregnancy at term.

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