Abstract
Serum α2-glycoprotein (α-2-GP) synthesis as a quantitative expression of tissue injury was studied in relation to various parameters by which glucocorticoid activity is measured. Involvement of the pituitary-adrenal axis was indicated by the fact that α-2-GP response to inflammation was similarly inhibited in animals having undergone adrex, or hypox, or both ablative procedures. Although an inverse relationship existed between thymolysis and serum α-2-GP levels in traumatized adrexed animals receiving cortisol, thymolysis could be induced without concomitant α-2-GP synthesis by cortisol treatment of nontraumatized rats. Furthermore, α-2-GP synthesis could be induced in traumatized rats that had been thymectomized at birth. Saline extracts of both thymus and spleen produced no precipitin reactions with the specific α-2-GP reagent. A comparison of liver glycogen levels with serum α-2-GP titers in cortisol treated and nontreated animals animals having undergone various surgical procedures indicated that α-2-...
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