Abstract

The membrane-free cytosol of pig brain contains glycolipid transfer protein (GL-TP), which in vitro facilitates the transfer of various glycosphingolipids and glyceroglycolipids between membranes. This protein has been purified to homogeneity from this source. GL-TP from pig brain transfers glycolipids with a sglucosyl or s-galactosyl residue directly linked to either ceramide or diacylglycerol. Antisera raised against pig GL-TP in rabbits are cross-reactive with rat, mouse, and human GL-TP, GL-TP appears to be present in many animal cells, since it has been found in all cell lines of rat, mouse, pig, and human origins examined so far for the protein. GL-TP has been partially purified from bovine brain and spleen, rat brain and liver, and human spleen. Evidence has been obtained indicating that GL-TP is a cytoplasmic protein.

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