Abstract
Diabetes mellitus is a metabolic syndrome that causes impairment, mortality, and many other complications. Insulin and several synthetic medications are currently used in the treatment of diabetes. However, these pharmaceutical drugs are costly, and therefore medicines place priority on alternatives to fight this lethal disease. This modest study aims to investigate the chemical composition, antidiabetic and antihyperglycemic potentials along with subacute toxicity (bodyweight change and biochemical parameters) of hydroethanol extract from Withania frutescens L. roots (WFRE). The chemical analysis was carried out using GC–MS after extract silylation. The chemical analysis identified many potentially active compounds that may determine the antidiabetic results of WFRE. The antidiabetic effect of WFRE was evaluated in mice with severe diabetes using oral administration of doses up to 400 mg/kg for 28 days. The results of the antidiabetic and antihyperglycemic tests indicate that WFRE possesses promising glucose-lowering effects and, as a result, it may serve as an antidiabetic alternative for long-term use. The 4-week treatments with different doses of plant extract did not alter the bodyweight appearance of the diabetic mice nor their biochemical parameters (AST and ALT). The findings obtained indicate that the studied plant extract controlled severe diabetes in mice. Therefore, Withania frutescens L. can serve society as it provides natural agents to control diabetes.
Highlights
Sugar diabetes is a metabolic condition with elevated levels of blood sugar arising from an insulin insufficiency in Langerhans pancreatic islet cells or from its inefficacy [1].Classified as a chronic medical condition, people with diabetes struggle with unstable blood glucose and the complications that come with it during their entire lifetime [2]
The present study aimed to investigate the in vivo antidiabetic effect of hydroethanol extract from W. frutescens roots in both alloxan-induced diabetic and normal mice
During the whole for 400 mg/kg; 133 ± 18 mg/dL for glibenclamide). These results indicate a moderate antiexperimental period, diabetic mice treated with the plant extract showed an increase in diabetic effect of Withania frutescens L. roots (WFRE) when compared to the standard antidiabetic drug
Summary
Sugar diabetes is a metabolic condition with elevated levels of blood sugar arising from an insulin insufficiency in Langerhans pancreatic islet cells or from its inefficacy [1]. Classified as a chronic medical condition, people with diabetes struggle with unstable blood glucose and the complications that come with it during their entire lifetime [2]. Medicinal plants have been used as an extensive medication source to control disease since more than. A variety of active ingredients have been purified from plants for direct use as medicines or to function as lead compounds or drug candidates [12]. (W. frutescens) is a woody plant belonging to the family Solanaceae with enormous chemical compounds in its composition. The genus Withania possesses several activities, including anti-inflammatory, antituberculosis, and antioxidant ones [13]. To discover further biological activities that may exist in the genus Withania, the current work was undertaken to investigate the chemical composition and the antidiabetic and antihyperglycemic effects of W. frutescens roots using alloxan-induced diabetic methods
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