Abstract
BackgroundThe association of the three Glutathione S-transferases (GSTs) polymorphisms (GSTM1, GSTT1 and GSTP1) genotypes with their individual susceptibilities to renal cell carcinoma (RCC) has not been well established. We performed a quantitative meta-analysis to assess the possible associations between the GSTM1, GSTT1 and GSTP1 genotypes and their individual susceptibilities to renal cell carcinoma.MethodsWe systematically searched the PubMed, CNKI and Embase databases to identify the relevant studies. Finally, 11 eligible studies were selected. The pooled odds ratios (ORs) with their 95% confidence intervals (CIs) were used to assess the association between the GSTs polymorphisms and the risk of RCC. Multiple subgroup analyses and quality assessment of the included studies were performed based on the available information.ResultsNone of the GSTs polymorphisms had a significant association with the RCC risk. Similar results were found in the subgroup analyses, except for the GSTs polymorphisms in the situations described below. The GSTM1 and GSTT1 active genotypes in subjects exposed to pesticides (GSTM1: OR = 3.44; 95% CI, 2.04–5.80; GSTT1: OR = 2.84; 95% CI, 1.75–4.60), most of the GSTs genotypes in Asian populations (GSTT1: OR = 2.39, 95% CI = 1.63–3.51; GSTP1: Dominant model: OR = 1.50, 95% CI = 1.14–1.99; Additive model: OR = 1.39, 95% CI = 1.12–1.73; AG vs. AA: OR = 1.47, 95% CI = 1.10–1.97; GG vs. AA: OR = 1.82, 95% CI = 1.07–3.09) and the dual null genotype of GSTT1-GSTP1 (OR = 2.84, 95% CI = 1.75–4.60) showed positive associations with the RCC risk.ConclusionOur present study provides evidence that the GSTM1, GSTT1 and GSTP1 polymorphisms are not associated with the development of RCC. However, more case-control studies are needed for further confirmation.
Highlights
In 2008, approximately 271,000 cases of kidney cancer were diagnosed around the world, and 116,000 individuals died of kidney cancer [1]
1718 cases and 2912 controls were included for the analysis of the GSTM1 genotype, 1721 cases and 2907 controls were used for the analysis of the GSTT1 genotype and 792 cases and 1491 controls were included for the analysis of the GSTP1 genotype
We found that none of these three Glutathione S-transferases (GSTs) polymorphisms had a significant association with the susceptibility to renal cell carcinoma (RCC)
Summary
In 2008, approximately 271,000 cases of kidney cancer were diagnosed around the world, and 116,000 individuals died of kidney cancer [1]. Renal cell carcinoma (RCC) accounts for the majority of kidney cancers (80–85%) and is the third most commonly diagnosed genitourinary malignancy [2]. RCC only develops in a small group of people who are exposed to the above factors, which suggests that genetic host factors might contribute to the carcinogenic mechanisms. The evidence indicates that the development of RCC can be partially explained by genetic variations among the populations. The association of the three Glutathione S-transferases (GSTs) polymorphisms (GSTM1, GSTT1 and GSTP1) genotypes with their individual susceptibilities to renal cell carcinoma (RCC) has not been well established. We performed a quantitative meta-analysis to assess the possible associations between the GSTM1, GSTT1 and GSTP1 genotypes and their individual susceptibilities to renal cell carcinoma
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