Abstract
Objective Patients with joint disease are often plagued by chronic pain and arthroscopy is an effective and minimally invasive procedure for diagnosis and treatment. But long- term painful torture may cause the change for brain structure and function. This study sought to evaluate the effect of long- term pain on brain metabolism. Methods This study was a prospective cohort study performed between August 2016 and December 2016. Patients were subjected to arthroscopic surgery for joint diseases. A visual analog scale (VAS) was used to measure pain intensity. The magnetic resonance spectroscopy (MRS) was used to identify the concentration of neuro- metabolites in the periaqueductal gray (PAG) and medial prefrontal cortex (mPFC) before and after arthroscopies. Results Eight patients with chronic pain and 7 without chronic pain were enrolled. The mean age was 32 years ole. In the patients with chronic pain, glutamic acid and glutamine (Glx) in PAG were elevated after operation (1.64±0.46 vs. 1.22±0.23). The patients with chronic pain had a higher post- operation Glx of PAG than controls (1.64±0.46 vs. 1.21±0.19). Conclusion There was a glutamatergic disturbance after arthroscopy in the non- elderly patients with chronic pain. Key words: Chronic pain; Arthroscopy; Joint disease; Magnetic resonance spectroscopy; Periaqueductal gray
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