Abstract
1. 1. Rat hemidiaphragms incubated in uremic sera utilize less glucose than those incubated in control sera. Uremic sera do not inhibit the utilization of fructose. 2. 2. The concentrations of free glucose, glucose 6-phosphate and fructose 6-phosphate in diaphragms incudated in uremic sera rise, the concentration of fructose 1,6-diphosphate falls, indicating the crossover point at the level of phosphofructokinase. 3. 3. Uremic sera decrease the concentrations of pyruvate, citrate and α-ketoglutarate in diaphragms, but do not influence the concentrations of adenosine tri-, di-, or monophosphate. It is concluded that uremic sera inhibit primarily the activity of phosphofructokinase in diaphragms. The significance of citrate or adenosine phosphates in evoking this inhibition was excluded.
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