Abstract
Glucose metabolism in young rat skin slices has been studied with the aid of glucose-1-C 14, glucose-6-C 14, and glucose-U-C 14. A balance study showed that after 3 hr. about 36% of the starting glucose was converted to carboxylic acids (lactic, acetic, and formic), about 2% was oxidized to CO 2, 5% appeared as amino acids. 5% as phosphorylated compounds, and 28% as residual hexose. Lactic acid accounted for nearly all of the C 14 in the acidic material. Lactate degradation results showed the operation of the Embden-Meyerhof pathway. Glucose-1-C 14 was somewhat better as a source of C 14O 2 than was glucose-6-C 14, indicating qualitative evidence, for the presence of a pentose cycle. This is the first report of the presence of formic acid in skin. As glucose carbon is a poor source of formic acid, most of the compound was produced from endogenous sources.
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