Abstract
We have previously shown that glycemic instability, as measured by the coefficient of variation for fasting plasma glucose (CV-FPG), is an independent predictor of cardiovascular mortality in type 2 diabetes (1,2). The mechanisms, if any, underlying the association between long-term plasma glucose instability and vascular diseases are difficult to explain. In vitro studies with retinal capillary pericytes have shown that rapid glucose fluctuations in the culture medium induced cellular damage and death by apoptosis (3). Moreover, tubulointerstitial cells exposed to intermittent high glucose concentrations underwent changes in cellular growth, collagen synthesis, and cytokine secretion that were more severe than those observed in cells exposed to stable high-glucose concentrations (4). These data extrapolated …
Highlights
W e have previously shown that glycemic instability, as measured by the coefficient of variation for fasting plasma glucose (CV-FPG), is an independent predictor of cardiovascular mortality in type 2 diabetes [1,2]
The cutoff of CV-FPG was chosen based on the results of our previous study: a CV-FPG Ͻ15% was associated with the lowest cardiovascular mortality rate, whereas a CV-FPG Ͼ25% predicted the highest cardiovascular mortality rate [1,2]
Circulating levels of E-selectin, Pselectin, intracellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1 were measured in all patients between November 2000 and December 2000 by enzyme-linked immunoassay (Bender Medsystems), with intra- and interassay CVs Ͻ8%
Summary
Taniguchi A, Fukushima M, Sakai M, Miwa K, Makita T, Nagata I, Nagasaka S, Doi K, Okumura T, Fukuda A, Kishimoto H, Fukuda T, Nakaishi S, Tokuyama K, Nakai Y: Remnant-like particle cholesterol, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients. Taniguchi A, Fukushima M, Sakai M, Kataoka K, Miwa K, Nagata I, Doi K, Tokuyama K, Nakai Y: Insulin-sensitive and insulin-resistant variants in nonobese Japanese type 2 diabetic patients (Letter). Taniguchi A, Fukushima M, Sakai M, Kataoka K, Nagata I, Doi K, Arakawa H, Nagasaka S, Tokuyama K, Nakai Y: The role of the body mass index and triglyceride levels in indentifying insulin-sensitive and insulin-resistant varaints in Japanese non-insulin-dependent diabetic patients.
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