Abstract
We propose a novel optical method for glucose measurement based on diffuse photon-pair density wave (DPPDW) in a multiple scattering medium (MSM) where the light scattering of photon-pair is induced by refractive index mismatch between scatters and phantom solution. Experimentally, the DPPDW propagates in MSM via a two-frequency laser (TFL) beam wherein highly correlated pairs of linear polarized photons are generated. The reduced scattering coefficient [Formula: see text] and absorption coefficient [Formula: see text] of DPPDW are measured simultaneously in terms of the amplitude and phase measurements of the detected heterodyne signal under arrangement at different distances between the source and detection fibers in MSM. The results show that the sensitivity of glucose detection via glucose-induced change of reduced scattering coefficient ([Formula: see text]) is 0.049%[Formula: see text]mM[Formula: see text] in a 1% intralipid solution. In addition, the linear range of [Formula: see text] vs glucose concentration implies that this DPPDW method can be used to monitor glucose concentration continuously and noninvasively subcutaneously.
Highlights
We propose a novel optical method for glucose measurement based on di®use photon-pair density wave (DPPDW) in a multiple scattering medium (MSM) where the light scattering of photonpair is induced by refractive index mismatch between scatters and phantom solution
The results show that the sensitivity of glucose detection via glucose-induced change of reduced scattering coe±cient mM À1 in a
Conventional approaches to measuring glucose in a nonscattering medium uses optical rotation of linear polarized light and detection of the amplitude or phase change of the emergent polarized laser beam vs the incident beam.[1,2]
Summary
We propose a novel optical method for glucose measurement based on di®use photon-pair density wave (DPPDW) in a multiple scattering medium (MSM) where the light scattering of photonpair is induced by refractive index mismatch between scatters and phantom solution. Conventional approaches to measuring glucose in a nonscattering medium uses optical rotation of linear polarized light and detection of the amplitude or phase change of the emergent polarized laser beam vs the incident beam.[1,2] For glucose measurements in a multiple scattering medium (MSM), larger error results from optical rotation angle measurements. This is due to multiple scattering that induces multiple optical path lengths of laser beam in the media. Glucose in MSM can reduce the light scattering due to a reduced refractive index mismatch between scatters and the surrounding medium
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