Abstract
Summary The effect of glucagon on neutral amino acid transport systems was studied in freshly-prepared suspensions of isolated hepatocytes by measuring basal and hormone-stimulated α-aminoisobutyric acid (AIB) and cycloleucine uptake. Glucagon stimulated AIB uptake against a concentration gradient. Half-maximal stimulation occured with 0.4 nM glucagon. Glucagon stimulation was restricted to the A mediation of transport. The effect was rapid, occured without time lag, was abolished by cycloheximide and mimicked by dibutyryl cyclic AMP.
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