Global health burden of cirrhosis and other chronic liver diseases (CLDs) due to non-alcoholic fatty liver disease (NAFLD): A systematic analysis for the global burden of disease study 2019

Abstract

BackgroundNon-alcoholic fatty liver disease (NAFLD) has emerged as a significant health issue due to its association with a growing proportion of cirrhosis and other chronic liver diseases (CLDs). To obtain a profound understanding of the burden of cirrhosis and other CLDs due to NAFLD, we aim to present a comprehensive analysis from 1990 to 2019. MethodsThe study utilized data from the Global Burden of Disease database. ResultsFrom 1990 to 2019, the global incidence, prevalence, death, and disability-adjusted life year (DALY) numbers increased 93%, 120%, 77%, and 62%, respectively. Despite the age-standardized death rate (ASDR) and the age-standardized DALY decreased, the age-standardized incident rate (ASIR) and age-standardized prevalent rate (ASPR) increased from 1.50 to 1.63 and 12065.15 to 15022.90 per 100,000 people, respectively. A higher incidence rate was observed among middle-aged individuals, while a higher prevalence, death, and DALY rates were among the elderly. Males remained higher number of prevalence, death, DALY cases than females. The low-middle and high socio-demographic index (SDI) region had the highest increase of ASIR and ASPR, respectively. The low SDI region had the largest decrease in ASDR and age-standardized DALY. ConclusionsAn increasing cases of cirrhosis and other CLDs due to NAFLD was observed. The ASIR and ASPR showed a worsening trend, while ASDR and age-standardized DALY showed an improving trend. Middle-aged and older people are more susceptible. Males experienced a higher burden than females.