Abstract
Objective: To determine the effect of CO 2 inhalation on global cerebral blood flow (gCBF) and p CO 2 -adjusted gCBF in normal subjects and panic disorder patients. Method: Global cerebral blood flow was determined using quantitative [ 15 O ]water imaging in normal subjects ( n=12) and panic disorder patients ( n=14) after inhalations of medical grade air and of 35%/65% CO 2/O 2 mixture, a known inducer of panic. The gCBF was calculated as an area-weighted mean value. The p CO 2 -adjusted gCBF values were calculated based on the formula of Reiman et al. [Am. J. Psychiatr. 143 (1986) 469]. Data were analyzed using repeated-measures ANOVA and regression analyses. Results: The p CO 2 values did not differ statistically between normals and panic patients. Panic patients exhibited a decrease in gCBF and stable p CO 2 -adjusted gCBF values in comparisons of AIR and CO 2 inhalations, whereas normals exhibited stable gCBF and increasing p CO 2 -adjusted gCBF values. Conclusions: Patients with panic disorder, especially when symptomatic, exhibited an abnormal pattern in gCBF response to provocation.
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