Abstract
Hepatitis B virus (HBV) remains a major global health problem, with approximately 257 million people chronically infected. HBV co-infection with human immunodeficiency (HIV) virus is a major public health problem especially in developing countries. In this study, the genotypes of HBV were determined among 400 consenting HIV patients accessing healthcare in Federal Medical Center, Keffi, Nigeria by Nested Multiplex PCR method. Blood samples were collected and screened for HBsAg using ACON kit (ACON Laboratories Inc, USA). HBV DNA from 18 positive samples were genotyped. Of these, 5.6% were of genotype B, 22.2% were of genotype F and 72.2% were not-typeable. This study reported the circulation of genotypes B and F in the study population with predominance of not-typable strains. To the best of our knowledge, this is the first report of genotype F in a Nigerian study.
Highlights
Hepatitis B virus (HBV) remains a major global health problem, with approximately 257 million people chronically infected [1]
This study reported the circulation of genotypes B and F in the study population with predominance of not-typable strains
The B genotype was from a male, between the ages of 40-49 years, he was divorced, had a tertiary education, and an artisan from the rural setting
Summary
Hepatitis B virus (HBV) remains a major global health problem, with approximately 257 million people chronically infected [1]. HBV, HCV and HIV are blood borne viral infections that have been widely reported in Nigeria [2]. HBV accounts for most viral hepatitis associated deaths [3]. It is endemic in Africa and Western Pacific, with about 6% chronic infections in adults [1]. In Nigeria, HBV is reported to be the most common cause of liver disease [4]. There is paucity of HBV genotyping data in Nigeria. The knowledge of the circulating genotypes is important for optimal treatment strategy especially in chronic patients. The aim of this study was to detect the HBV genotypes circulating in the study area from individuals accessing healthcare in Federal Medical Centre, Keffi, Nigeria
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