Genotypic and allelic frequencies analysis of the 19 T˃G polymorphism of the UGT1A6 gene in Mexican mestizo population of the state of Puebla

Abstract

UGT1A6 catalyzes the glucuronidation of several xenobiotics and drugs widely used. Changes in the glucuronidation rate are attributed to inter-personal and inter-ethnic variations, that can impact the expression or enzyme function. Frequencies of genetic polymorphisms of UGT1A6 have been reported in another countries; however, there are no date of frequencies in the Mexican population. The aim of this work was to determine the genotypic and allelic frequencies of UGT1A6 19T˃G in a Mexican mestizo population of the state of Puebla and compare them with the frequencies observed in other populations. Peripheral blood DNA was obtained from 60 healthy adults and 19 T˃G alleles were identified by the PCR-RFLP technique. Our results were compared with those observed in other ethnic groups, and we observed that our frequencies were lower than those reported in Chinese, Korean, Japanese, Hindu, and Greek populations. These results must be considered to make decisions when choosing the drugs administered to different ethnic groups.