Abstract
Cancer is a disease of the genome caused by an accumulation of genetic and epigenetic alterations in oncogene and tumor suppressor genes drawing the landscape of human tumors. In liver tumors, like in other human cancers, TP53 (for tumor protein 53) is the most frequently inactivated tumor suppressor gene. TP53 mutations are identified in 20%–50% of hepatocellular carcinoma (HCC)1 with a highest frequency of mutations in Asia and Africa owing to chronic hepatitis B infection and aflatoxin B1 (a mycotoxin contaminating peanut, rice, and corn) exposure.
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