Abstract
Genomics and Metabolomics in Obesity and Type 2 Diabetes.
Highlights
The metabolome is influenced by genetic variants, epigenetic factors, changes in gene expression, or enzyme activity, as well as by environmental factors and aging [9]
Novel treatment strategies for obesity/T2DM are sought, while the already known effective treatments such as life style modification or weight loss surgeries should be studied in more detail to explore the molecular pathways lying underneath the weight loss and the T2DM remission
Among small molecule metabolites, branched-chain amino acids and acylcarnitines have been linked to obesityassociated insulin resistance (IR)
Summary
The metabolome is influenced by genetic variants, epigenetic factors, changes in gene expression, or enzyme activity, as well as by environmental factors (diet, physical activity, and pharmaceuticals) and aging [9]. Based on metabolomics studies, several small molecules are proposed as related to diabetes and/or obesity [10], and the utility of metabolomics for diet-related studies has already been shown [11]. Novel treatment strategies for obesity/T2DM are sought, while the already known effective treatments such as life style modification (physical activity, diet) or weight loss surgeries should be studied in more detail to explore the molecular pathways lying underneath the weight loss and the T2DM remission.
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