Abstract
Genomic DNA 5′ to the mouse and human genes encoding angiotensin-converting enzyme has been isolated and analyzed. A sequence comparison identifies two discrete regions of genomic DNA that are highly conserved. One region, found immediately 5′ to the mouse and human ACE genes, is a GC rich segment that contains a “TATA box” and several potential Spl binding sites. The second conserved region is found further 5′ and contains several potential regulatory cis elements including a possible glucocorticoid responsive element. These two regions of genomic DNA may influence the rate of mRNA transcription from the angiotensin-converting enzyme gene.
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