Abstract
A high-density oligonucleotide probe array (GeneChip) has been used to learn how gene expression is globally regulated by the circadian clock mechanism. Here I review five articles, including our own, describing the genome-wide identification of rhythmically expressed genes by a similar strategy using GeneChip in Drosophila under light-dark (LD) and constant dark (DD) conditions. These studies drew common conclusions in some aspects. A number of genes were cyclically expressed in fly heads and they were involved in diverse functions, suggesting the entire complexity of circadian gene expression in Drosophila. In addition, a global effect of clock mutations, ClkJrk, per0 and tim0, on gene expressions was commonly observed, implying that these clock genes are associated with the transcriptional regulation of a large number of genes.
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