Abstract
Coeruloplasmin has been studied on 3051 individuals from Swiss populations. The C*PA frequencies of 0.0050 reported for Northern Switzerland as well as for the Upper Rhone Valley (Brig, Goms) and the Visp Valleys (Valais) are in the range of those of other European populations. In the village of Törbel and in the Lötschental (both Canton of Valais) the C*PA frequencies are somewhat lower. The individuals from the French speaking part of Valais showed only the C*PB allele. The fixation of the C*PB allele in the Walser of the Safiental (The Grisons) can be explained under the assumption of founder effect or of genetic drift. A new CP variant (C*PW) is described.
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