Abstract
With the thorough understanding of stem cell biology and the advent of targeted therapeutics for cancer, stem cell-based therapeutic strategies are being increasingly explored in the treatment of various cancer types. However, the role of stem cell therapies in cancer treatment, especially within developing targeted therapies, has not been fully elucidated. The aim of this publication is to shed light on current studies of this nature, by focusing on the application of mesenchymal stem cells (MSC) in various cancers with emphasis on a number of aspects that are critical to the success of future stem cell-based therapies for cancer. These include stem cell sources, tumor specificity, targeted therapeutics, and visualizing the stem cell and therapeutic agent pharmacokinetics which will ultimately allow translation of preclinical studies into early phase clinical studies. This publication aims to inform readers about critical and cutting edge stem cell therapies for cancer and also enable them to appreciate the vast plain of unresolved questions in stem cell research for cancer therapeutics.
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