Abstract
The Scedosporium apiospermum species complex is an emerging filamentous fungi that has been isolated from environment. It can cause a wide range of infections in both immunocompetent and immunocompromised individuals. We aimed to study the genetic variation and relationships between 48 strains of S. apiospermum sensu stricto isolated from soil in Bangkok, Thailand. For PCR, sequencing and phylogenetic analysis, we used the following genes: actin; calmodulin exons 3 and 4; the second largest subunit of the RNA polymerase II; ß-tubulin exon 2–4; manganese superoxide dismutase; internal transcribed spacer; transcription elongation factor 1α; and beta-tubulin exons 5 and 6. The present study is the first phylogenetic analysis of relationships among S. apiospermum sensu stricto in Thailand and South-east Asia. This result provides useful information for future epidemiological study and may be correlated to clinical manifestation.
Highlights
The Scedosporium apiospermum species complex is a group of filamentous fungi that have been reported in cystic fibrosis (CF) patients [1]
In Thailand, S. apiospermum has been reported in brain abscesses of near-drowning and renal transplant patients [3,4], and S. boydii infections have been reported in brain tissue of renal transplant patient [5]
One previous study defined “S. apiospermum species complex” as comprising S. apiospermum, S. boydii, and Pseudallescheria angusta [7], but another study defined it as five species: S. apiospermum sensu stricto, S. boydii, S. aurantiacum, S. dehoogii, and S. minutispora [8]
Summary
The Scedosporium apiospermum species complex is a group of filamentous fungi that have been reported in cystic fibrosis (CF) patients [1]. It can be isolated from the environment, especially in human-impacted areas such as playgrounds, industrial and agricultural zones [2]. In Thailand, S. apiospermum has been reported in brain abscesses of near-drowning and renal transplant patients [3,4], and S. boydii infections have been reported in brain tissue of renal transplant patient [5]. Two Swiss tourists who nearly drowned in the tsunami disaster in Thailand were found to be infected with S. apiospermum [6].
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