Abstract
BackgroundAdiponectin acts as an antidiabetic, antiinflammatory and antiatherogenic adipokine. These effects are assumed to be mediated by the recently discovered adiponectin receptors AdipoR1 and AdipoR2.AimThe purpose of this study was to determine whether variations in the AdipoR1 and AdipoR2 genes may contribute to insulin resistance, dyslipidemia and inflammation.MethodsWe sequenced all seven coding exons of both genes in 20 unrelated German subjects with metabolic syndrome and tested genetic variants for association with glucose, lipid and inflammatory parameters.ResultsWe identified three AdipoR2 variants (+795G/A, +870C/A and +963C/T) in perfect linkage disequilibrium (r2 = 1) with a minor allele frequency of 0.125. This haplotype was associated with higher plasma adiponectin levels and decreased fasting triglyceride, VLDL-triglyceride and VLDL-cholesterol levels. No association, however, was observed between the AdipoR2 SNP cluster and glucose metabolism.ConclusionTo our knowledge, this is the first study to identify an association between genetic variants of the adiponectin receptor genes and plasma adiponectin levels. Furthermore, our data suggest that AdipoR2 may play an important role in triglyceride/VLDL metabolism.
Highlights
Adiponectin acts as an antidiabetic, antiinflammatory and antiatherogenic adipokine
This haplotype was associated with higher plasma adiponectin levels and decreased fasting triglyceride, very low density lipoprotein (VLDL)-triglyceride and VLDL-cholesterol levels
No association was observed between the adiponectin receptor 2 (AdipoR2) single nucleotide polymorphism (SNP) cluster and glucose metabolism. To our knowledge, this is the first study to identify an association between genetic variants of the adiponectin receptor genes and plasma adiponectin levels
Summary
Adiponectin acts as an antidiabetic, antiinflammatory and antiatherogenic adipokine. These effects are assumed to be mediated by the recently discovered adiponectin receptors AdipoR1 and AdipoR2. Adiponectin ( known as AdipoQ, APM1, and Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic [1,2,3,4,5], antiinflammatory [6,7], and antiatherogenic [8,9,10] adipokine. Adiponectin's antiinflammatory and antiatherogenic effects are thought to be mediated by inhibition of TNF-α induced nuclear factor-κB activation [19], inhibition of expression of adhesion molecules [20], decreased smooth muscle cell proliferation [8], and reduced foam cell formation [21]
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