Abstract
The results of direct selection for increased or decreased voluntary water intake at 22°C and 35°C are reported for the laboratory rat. Selection was more effective at 35°C with asymetrical response favoring selection for increased water consumption. Reciprocal transfer response of lines selected for increased water consumption was very comparable to direct selection at each temperature with a genetic correlation of 0.93. Transfer response of the negative selection groups was about half the direct response. Water restriction studies, urine concentration tests, adrenal, pituitary and kidney analyses showed no abnormal conditions in the high- or low-drinking groups that would account for the difference in water intake. The evidence indicates that the observed physiological differences between high- and low-water consuming groups were the result of effective selection for genetic differences in the thirst drive. Thus, the resulting adipsia and polydipsia may be defined as genetic variations of a psychogenic or behavioral trait.
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