Abstract
Genetic Analysis of Inhibin Alpha (INHα) Mutation (769G>A) in Patients with Premature Ovarian Failure in a Local Population
Highlights
Premature ovarian failure (POF) is the early loss of functional ovarian follicles in women under the age of 40 years
Patients (n = 50) presented with primary amenorrhea, secondary amenorrhea, unexplained infertility and 46, XX karyotype were included in the study
For all POF patients, serum follicle stimulating hormone (FSH) levels were within the range of 4.8 – 98 IU/L
Summary
Premature ovarian failure (POF) is the early loss of functional ovarian follicles in women under the age of 40 years. POF is a common clinical condition affecting 1 – 3% of women of the reproductive age group.[1,2] The condition is usually characterized by amenorrhea of 4 – 6 months along with abnormal levels of gonadotrophins (FSH > 30 IU/l) and hypoestrogenism. Women with POF may not experience a menstrual cycle at all (primary amenorrhoea) or may experience cessation of ovarian function after a period of menstrual cycling (secondary amenorrhoea). The common presentation is in the form of secondary amenorrhea or oligomenorrhea. The objective of the present study was to analyze the role of inhibin alpha (INHα) gene mutation (769G>A) in patients with premature ovarian failure (POF) in the local population
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