Abstract
The three expressed genes of the human serum amyloid A gene family ( SAA1, SAA2 and SAA4) have been isolated in four contiguous clones selected from a chromosome 11 cosmid library. Analysis of these clones revealed that SAA1 and SAA2 are located 18 kb apart in opposite transcriptional orientations, while SAA4 lies 11 kb downstream from SAA2 in the same orientation: 3′( SAA1)5′-18 kb-5′( SAA2)3′-11 kb-5′( SAA4)3′. A fifth SAA clone isolated from this library was noncontiguous with the other four and contained the SAA3 pseudogene.
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