Abstract
Here, we report the establishment of the human iPS cell line N1-FiPS4F#7 generated from skin cells of a patient with no rheumatic diseases, thus obtaining an appropriate control iPS cell line for researchers working in the field of rheumatic diseases. The reprogramming factors Oct4, Sox2, Klf4 and c-Myc were introduced using a non-integrating reprogramming strategy involving Sendai Virus.
Highlights
Genetic Modification Type of Modification Associated disease Gene/locus Method of modification Name of transgene or resistance Inducible/constitutive system Date archived/stock date
Resource utility iPSC-lines have been generated from patients with rheumatic diseases, there is still lack of appropriate control lines generated from patients with radiographic information regarding principal joints
Dermal fibroblasts were isolated from a skin biopsy of a donor with nor radiographic signs neither symptoms of rheumatic diseases using a protocol previously described (Vangipuram et al, 2013)
Summary
IPSC-lines have been generated from patients with rheumatic diseases, there is still lack of appropriate control lines generated from patients with radiographic information regarding principal joints (knee, hip, hands and/or spine). We generated a control iPS cell line from a donor with no rheumatic diseases, as proved radiographically
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